Dynamical Simulation of Effective Stem Cell Transplantation for Modulation of Microglia Responses in Stroke Treatment

Stem cell transplantation therapy may inhibit inflammation during stroke and increase the presence of healthy cells in brain. The novelty this work, is to introduce a new mathematical model stem transplanted treat stroke. This manuscript studies stability by using current biological information on as possible treatment for from microglia proposed represent dynamics various immune brain (resting microglia, pro-inflammation anti-inflammation microglia), tissue damage transplanted. based set five ordinary differential equations explores beneficial effects at early stages Runge–Kutta method used discuss analytically solve it numerically. results our simulations are qualitatively consistent with those observed experiments vivo, suggesting that could contribute rate ant-inflammatory decrease pro-inflammatory microglia. It found analysis simulation can help patients modulation response In conclusion, approach contributions study therapeutic strategies reduce stages.